If a stroke is ischemic, tissue plasminogen activator (tPA) must be given within what time frame?

If a stroke is ischemic, tissue plasminogen activator (tPA) must be given within what time frame?

• A. Within 3-4.5 hours of onset of symptoms
• B. Within 6 hours
• C. Within 12 hours
• D. Within 24 hours

Answer: (A)

When a stroke is ischemic, the clot blocking blood flow is dissolved with tPA to restore perfusion and limit brain injury, but the benefit depends on acting quickly. The evidence shows a meaningful chance of better outcomes if IV tPA is given within the first 3 to 4.5 hours from when symptoms began. Beyond this window, the likelihood of clot dissolution benefits drops and the risk of serious bleeding rises, so treatment is generally not recommended after 4.5 hours unless specific, highly individualized criteria apply. Before administering tPA, you also confirm there’s no hemorrhage on imaging and address any contraindications and blood pressure issues to minimize risk.

When a stroke is ischemic, the clot blocking blood flow is dissolved with tPA to restore perfusion and limit brain injury, but the benefit depends on acting quickly. The evidence shows a meaningful chance of better outcomes if IV tPA is given within the first 3 to 4.5 hours from when symptoms began. Beyond this window, the likelihood of clot dissolution benefits drops and the risk of serious bleeding rises, so treatment is generally not recommended after 4.5 hours unless specific, highly individualized criteria apply. Before administering tPA, you also confirm there’s no hemorrhage on imaging and address any contraindications and blood pressure issues to minimize risk.