Infants with botulism commonly present with which symptoms?

Infants with botulism commonly present with which symptoms?

• A. Constipation and generalized weakness with diminished DTRs
• B. Diarrhea and dehydration
• C. Fever and rash
• D. Seizures and vomiting

Answer: (A)

Infant botulism causes a symmetric, descending flaccid paralysis from botulinum toxin blocking acetylcholine release at neuromuscular junctions. The toxin also slows autonomic function, so GI motility is reduced and constipation is common. This combination leads to generalized weakness with diminished deep tendon reflexes. Other signs in infants can include a weak cry and poor suck, but fever, rash, diarrhea, seizures, or vomiting aren’t typical features. So constipation with generalized weakness and reduced reflexes best fits infant botulism.

Infant botulism causes a symmetric, descending flaccid paralysis from botulinum toxin blocking acetylcholine release at neuromuscular junctions. The toxin also slows autonomic function, so GI motility is reduced and constipation is common. This combination leads to generalized weakness with diminished deep tendon reflexes. Other signs in infants can include a weak cry and poor suck, but fever, rash, diarrhea, seizures, or vomiting aren’t typical features. So constipation with generalized weakness and reduced reflexes best fits infant botulism.