Memantine is used to treat which condition?

Memantine is used to treat which condition?

• A. Alzheimer's disease
• B. Parkinson's disease
• C. Multiple sclerosis
• D. Amyotrophic lateral sclerosis

Answer: (A)

Memantine works by blocking NMDA receptors, which reduces glutamate-driven excitotoxicity in the brain. This helps slow cognitive decline and manage symptoms in moderate-to-severe Alzheimer's disease, and it’s often used alongside a cholinesterase inhibitor. Parkinson's disease, multiple sclerosis, and ALS involve different disease mechanisms and do not primarily rely on NMDA receptor–mediated excitotoxicity, so memantine is not indicated for them. Therefore, the condition most appropriately treated with memantine is Alzheimer's disease.

Memantine works by blocking NMDA receptors, which reduces glutamate-driven excitotoxicity in the brain. This helps slow cognitive decline and manage symptoms in moderate-to-severe Alzheimer's disease, and it’s often used alongside a cholinesterase inhibitor. Parkinson's disease, multiple sclerosis, and ALS involve different disease mechanisms and do not primarily rely on NMDA receptor–mediated excitotoxicity, so memantine is not indicated for them. Therefore, the condition most appropriately treated with memantine is Alzheimer's disease.