What is a primary drug treatment for Addison's disease?

What is a primary drug treatment for Addison's disease?

• A. Corticosteroids
• B. Mineralocorticoids
• C. Antidepressants
• D. Diuretics

Answer: (A)

Deficiency of cortisol in Addison’s disease requires replacing the missing hormone. Corticosteroids (glucocorticoids) are the primary drug treatment because they restore the stress response, metabolism, and blood pressure regulation that cortisol normally provides. Hydrocortisone is commonly used since it closely mimics natural cortisol and even offers some mineralocorticoid activity, which helps with fluid and electrolyte balance. If aldosterone deficiency is also significant, an additional mineralocorticoid such as fludrocortisone may be added to maintain sodium and potassium levels and stable blood pressure. Antidepressants and diuretics don’t address the underlying hormone deficiency and aren’t used as the main treatment for Addison’s disease.

Deficiency of cortisol in Addison’s disease requires replacing the missing hormone. Corticosteroids (glucocorticoids) are the primary drug treatment because they restore the stress response, metabolism, and blood pressure regulation that cortisol normally provides. Hydrocortisone is commonly used since it closely mimics natural cortisol and even offers some mineralocorticoid activity, which helps with fluid and electrolyte balance. If aldosterone deficiency is also significant, an additional mineralocorticoid such as fludrocortisone may be added to maintain sodium and potassium levels and stable blood pressure. Antidepressants and diuretics don’t address the underlying hormone deficiency and aren’t used as the main treatment for Addison’s disease.