What is the first-line treatment for Kawasaki disease?

What is the first-line treatment for Kawasaki disease?

• A. IV immunoglobulin and aspirin to prevent coronary artery aneurysm
• B. High-dose steroids
• C. Antibiotics only
• D. Chemotherapy

Answer: (B)

Kawasaki disease is treated first to quickly quell inflammation and protect the heart, especially the coronary arteries. The best initial therapy combines intravenous immunoglobulin (IVIG) with high-dose aspirin. IVIG helps modulate the immune response and greatly lowers the risk of developing coronary artery aneurysms. High-dose aspirin provides anti-inflammatory effects during the acute phase and also acts as an antiplatelet to prevent clotting in inflamed coronary vessels. Starting treatment within the first 10 days of illness is important for reducing aneurysm risk. Steroids aren’t first-line therapy for initial treatment; they’re considered if IVIG fails to produce an adequate response or in certain high-risk situations. Antibiotics aren’t used unless there’s a concurrent infection, and chemotherapy isn’t indicated for Kawasaki disease.

Kawasaki disease is treated first to quickly quell inflammation and protect the heart, especially the coronary arteries. The best initial therapy combines intravenous immunoglobulin (IVIG) with high-dose aspirin. IVIG helps modulate the immune response and greatly lowers the risk of developing coronary artery aneurysms. High-dose aspirin provides anti-inflammatory effects during the acute phase and also acts as an antiplatelet to prevent clotting in inflamed coronary vessels. Starting treatment within the first 10 days of illness is important for reducing aneurysm risk. Steroids aren’t first-line therapy for initial treatment; they’re considered if IVIG fails to produce an adequate response or in certain high-risk situations. Antibiotics aren’t used unless there’s a concurrent infection, and chemotherapy isn’t indicated for Kawasaki disease.