Which intervention slows bone resorption in osteoporosis?

Which intervention slows bone resorption in osteoporosis?

• A. Weight-bearing exercises
• B. Calcium and Vitamin D supplementation
• C. Bisphosphonates
• D. Stop smoking and alcohol

Answer: (C)

Bone loss in osteoporosis comes from bone resorption exceeding formation, so slowing resorption helps protect bone density and reduce fractures. Bisphosphonates are antiresorptive medications that bind to bone mineral and are taken up by osteoclasts, where they inhibit osteoclast activity and promote their apoptosis. This directly lowers bone turnover, leading to increased bone density over time and a lower fracture risk. Other options, like weight-bearing exercises, calcium and vitamin D supplementation, and stopping smoking or reducing alcohol, support bone health and reduce risk factors, but they do not directly and as effectively slow osteoclast-mediated resorption like bisphosphonates do.

Bone loss in osteoporosis comes from bone resorption exceeding formation, so slowing resorption helps protect bone density and reduce fractures. Bisphosphonates are antiresorptive medications that bind to bone mineral and are taken up by osteoclasts, where they inhibit osteoclast activity and promote their apoptosis. This directly lowers bone turnover, leading to increased bone density over time and a lower fracture risk.

Other options, like weight-bearing exercises, calcium and vitamin D supplementation, and stopping smoking or reducing alcohol, support bone health and reduce risk factors, but they do not directly and as effectively slow osteoclast-mediated resorption like bisphosphonates do.