Which statement about peripheral neuropathy due to INH is correct?

Which statement about peripheral neuropathy due to INH is correct?

• A. Nausea
• B. Dizziness
• C. Headache
• D. Tingling or numbness in hands and feet

Answer: (D)

Peripheral neuropathy from isoniazid presents as sensory changes in the distal extremities due to depletion of vitamin B6, which is needed for proper nerve function. The hallmark sign is tingling, burning, or numbness in the hands and feet (a stocking-glove distribution). This specific symptom reflects nerve involvement rather than nonspecific symptoms like nausea, dizziness, or headache, which can occur with many medications but don’t pinpoint peripheral neuropathy. Prophylactic vitamin B6 is often given to prevent this complication, and if neuropathy develops, management includes addressing the B6 deficiency and reassessing therapy as needed.

Peripheral neuropathy from isoniazid presents as sensory changes in the distal extremities due to depletion of vitamin B6, which is needed for proper nerve function. The hallmark sign is tingling, burning, or numbness in the hands and feet (a stocking-glove distribution). This specific symptom reflects nerve involvement rather than nonspecific symptoms like nausea, dizziness, or headache, which can occur with many medications but don’t pinpoint peripheral neuropathy. Prophylactic vitamin B6 is often given to prevent this complication, and if neuropathy develops, management includes addressing the B6 deficiency and reassessing therapy as needed.